Clinical Evidence
NOL in Posters, Abstracts and Presentations
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Personalized anesthesia is coming – introducing a novel triad monitoring solution
Weissbrod R, Hulvershorn J
STA Annual Meeting January 2026 -
Reliability of nociception level index monitoring in general anesthesia: a systematic review
S. Ferraioli, V. Donatiello, M.C. Pace, M.B. Passavanti, P. Sansone
Journal of Anesthesia, Analgesia and Critical Care October 2025 -
Experience with continuous remimazolam infusion in patients undergoing radiofrequency treatment for hepatocellular carcinoma
M. Barberio, C. Minucci, S. Virno, D. Abbenante, R. Giurazza, R. De Rosa
Journal of Anesthesia, Analgesia and Critical Care October 2025 -
Investigation of the NOL Index for Pain Assessment in ICU for Burn Patients: A Prospective Study
Anastasia Boptsi, Felix H. Stang, Anja M. Boos, Sophie Schleußer
European Burns Association September 2025 -
Anesthetic management of pheochromocytoma surgery. Case series
Zaragoza Garcia I., Luis Garcia C., Fernandez Castineira A., Puyada Jauregui M., Llaja C., Trilo Urrutia, L..
ESAIC Abstracts June 2025 -
Influence of intraoperative nociception guided analgesia on perioperative analgesia consumption in patients undergoing laparoscopic resection of endometriosis
Ranner P., Morselli H.T., Piskor T., Marcolino I.
ESAIC Abstracts June 2025 -
Evaluating nociception during general anaesthesia: a comparison of the Analgesia Nociception Index and the Nociception Level Index
Kempe H., Kreuzer M., Schneider G., Gambús P., Vide, S.
ESAIC Abstracts June 2025 -
Opioid-sparing anaesthesia in thymectomy using ultrasound-guided bilateral deep parasternal block: a case report
Sifaki F., Delis K., Michail N., Koraki E.
ESAIC Abstracts June 2025 -
Nociception Level Index Guided Perioperative Pain Management in Paediatric Patients
Berna Caliskan, Dilara Pınar Daglar
Regional Anesthesia & Pain Medicine, September 2024 -
Comparison of conventional epidural and dural puncture epidural analgesia techniques in gynecological surgeries guided by intraoperative nociception level index: a prospective randomized double-blind study
Karapınar, Y.E., Dostbil, A., Aksoy, M., Kasali, K., Senocak G.N.C., Ince, I.
Regional Anesthesia & Pain Medicine, September 2024 -
Effect of nociception level-directed analgesic management on opioid usage in robot-assisted laparoscopic radical prostatectomy: a single-center single-blinded randomized controlled trial (NOLDOR study)
Nobuhiro Tanaka, Yuma Kadoya, Takanori Suzuka, Takayuki Yamanaka, Mitsuru Ida, Naoki Ozu, Masahiko Kawaguchi
WCA, March 2024 -
Improving Provider Pain Assessment with Nociceptive Level Index
Deniz Dishman, PhD, CRNA, NSPM-C
ERAS-USA, February 2024 -
Generalizability of nociception level across various types of anesthesia: a retrospective analysis
Ott S, Ruetzler K, Sessler DI
STA Annual Meeting, January 2024 -
Evaluation of the Validity of Non-Invasive Nociception Monitoring in the Context of Intracranial Surgery
Robert Ruemmler, M.D., Vesselina Moravenova, Student, Sandy Al-Butmeh, M.D., Kimiko Fukui-Dunkel, M.D., Alexander Ziebart, M.D.
ASA, October 2023, ANESTHESIOLOGY Annual Meeting, A3260 -
Evaluating the Impact of NOL-Guided Anesthetic on Intra-Operative Opioid Dosing
Evan Cohen, B.A.; Gabrielle Veilleux, B.A.; Daniel Katz, M.D.
ASA, October 2023, ANESTHESIOLOGY Annual Meeting -
Assessing Nociception Level in Pediatric Patients Under General Anesthesia - an Observational Study
Justin Kong, B.S., Proshad N. Efune, M.D., Kiley F. Poppino, B.S., Peter Szmuk, M.D., Rita Saynhalath, M.D.
ASA, October 2023, ANESTHESIOLOGY Annual Meeting; A1111 -
Generalizability of Nociception Level (NOL) as a Measure of Intraoperative Nociceptive Stimulation
Maedeh Zokaei Nikoo, M.D., Kurt Ruetzler, M.D., Mateo Montalvo, M.D., Omer Miller Rotem, Elyad Ekrami, M.D., Julian Rössler, M.D., Jorge Andres Araujo Duran, M.D., Alparslan Turan, M.D., Daniel I. Sessler, M.D.
ASA, October 2023, ANESTHESIOLOGY Annual Meeting; A3248 -
NOL: Retrospective Analysis of Peridural Anesthesia
Alexander Ziebart, M.D., Jonas Rothgerber, M.D., Eva Griemert, M.D., Robert Ruemmler, M.D.
ASA, October 2023, ANESTHESIOLOGY Annual Meeting; A1010 -
Vorhersage von Schmerzreaktionen auf endotracheales Absaugen bei Intensivpatienten
Viktor Bublitz, Carlo Jurth, Falk von Dincklage
DAC 2022 -
Influence Of Sedatives On Nociception Level-guided Analgesia In Covid And Non-covid Intensive Care Unit Patients
Lea Imeen Van Der Wal, M.D., M.Sc., Jetske Van Der Bos, M.D., M.Sc., Evert de Jonge, M.D.,Ph.D., Albert Dahan, M.D.,Ph.D.
ASA, October 22, The Anesthesiology Annual Meeting; A4054 -
Nociception-guided Intraoperative Analgesia For Improved Postoperative Recovery: A Randomized Trial
Julian Rössler, M.D., Mateo X. Montalvo Campana, M.D., Hani A. Essber, M.D., Omer Bakal, M.D., Kamal Maheshwari, M.D., Alparslan Turan, M.D., Edward J. Mascha, Ph.D., Kurt Ruetzler, M.D.
ASA, October 2022, The Anesthesiology Annual Meeting; A1067 -
Detecting alveolar recruitment maneuvers with nociception monitors: a prospective cohort study
Coeckelenbergh S., Patricio D., Doria S., Barvais L., Perrin L.
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Nociception level index-guided antinociception versus standard care during remifentanilpropofol anesthesia for moderate-to-high risk cardiovascular surgery: a randomised controlled trial
Coeckelenbergh S., Doria S., Jaubert L., Engelman E., Barvais L., Perrin L.
Euroanaesthesia 2022, European Journal of Anaesthesiology; 39(e-Suppl.60) -
Influence of intraoperative nociception during orthopaedic joint surgery under supplementary regional anaesthesia on postoperative pain experience and postoperative opioid consumption
Neumann C., Wittmann M., Weinhold L., Gehlen L., Kornilov E., Thudium M.
Euroanaesthesia 2022, European Journal of Anaesthesiology; 39(e-Suppl.60) -
Is NOL index variation with surgical incision able to predict opioid consumption?
Chaban Y., Tabolcea I., Zec T., Hublet S., Colesnicenco A., Szegedi L.
Euroanaesthesia 2022, European Journal of Anaesthesiology; 39(e-Suppl.60) -
Does NoL monitoring affect opioid consumption during da Vinci prostatectomy?
Niebhagen, F., Golde, C., Koch, T., & Hübler, M.
Die Anaesthesiologie, 2022 10.1007/s00101-022-01126-7. Advance online publication. -
CIRUGÍA NO CARDÍACA GUIADA CON TECNOLOGÍA DE NOCICEPCIÓN NOL FRENTE A LA NO GUIADA: COMPARATIVA DE COSTES EN EL ENTORNO ESPAÑOL
Antonio Montes, Juan Carlos Luis Navarro, María Álvarez, Beatriz Pellicer, Rhodri Saunders, Carlos Ferrando
SEDAR, 2022 -
Nociception Level (NOL) as a measure of nociceptive stimuli: a retrospective analysis of 8 prospective studies
Montalvo-Campana, M, Overdyk, F, Rotem, O, Sessler, D & Ruetzler, K.
PGA, December 2021, Anesthesiology; 75 -
Nociception Level-guided balanced general anesthesia favorably influences acute postoperative pain after elective major abdominal surgery
Cindea I., Balcan A., Gherghina V., Samoila B., Prazaru M., Popescu R.
ESAIC, December 2021, European Journal of Anaesthesiology; 38(Suppl. 59)) -
Effect of preinduction low-dose ketamine bolus on intra-operative opioid requirements during Nociception Level Index guided antinociception: A randomized controlled trial
Gherghina V., Cindea I., Balcan A., Prazaru M., Popescu R., Costea D.
ESAIC, December 2021, European Journal of Anaesthesiology; 38(Suppl. 59)) -
Opioid-free anesthesia guided by NoL® monitor in bariatric surgery. Reduction of postoperative pain and PONV – Case Report
Toral Toral U., Salas Rezola E., Galiana Ivars M., Navarro Martinez J.1, Ferrero Coloma C.
ESAIC, December 2021, European Journal of Anaesthesiology; 38(Suppl. 59)) -
Predicting personalised remifentanil effect site concentration for surgical incision with a nociception level index: a prospective calibration and validation study
Perrin L., Bisdorff M., Saxena S., Engelman E., Barvais L., Coeckelenberg S.
ESAIC, December 2021, European Journal of Anaesthesiology; 38(Suppl. 59)) -
Changes in the Nociception Level Index During Surgical Resection of Paragangliomas: A Case Report
Saynhalath, R., Khan, U., Alex, G., Murphy, J., Szmuk, P.
A & A Practice: November 2021 - Volume 15 - Issue 11 - p e01542) -
Nociception Measurement In Ventilated Covid And Non-covid Patients In The Intensive Care Unit
Van Der Bos, J., van der Wal, I., De Jonge, E., Dahan, A.
ASA, October 2021, The Anesthesiology Annual Meeting; A2005 -
Reduced Postoperative Pain In Patients Receiving Nociception Monitor Guided Analgesia During Elective Surgery
Fuica, R., Krochek, C., Greenman, D., Freundlich, A., Gozal, Y..
ASA, October 2021, The Anesthesiology Annual Meeting; A2066 -
A comparison of intraoperative pain measurement with the PMD 200 in fentanyl-based and low opioid anaesthesia: a prospective monocenter pilot study
Schwab, P., Steiner, L., Bandschapp, O.
SGAR, Switzerland, October 2020, Swiss Medical Weekly 2020;150 (Suppl. 246) -
Reduced Postoperative Pain In Patients Receiving Opioid-dosing Based On An Artificial Intelligence-driven Nociception Monitor During Elective Noncardiac Surgery
Albert Dahan, M.D.,Ph.D., Fleur Meijer, M.D., Tessa Roor, M.D., Samantha Toet, M.D., Paul Calis, M.D., Martijn Boon, M.D.,Ph.D., Christian Martini, M.D.,Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D.,Ph.D.
ASA, Virtual (USA), October 2020 -
Impact de l'analgésie peropératoire guidée par le niveau de nociception sur la consommation d'opioïdes intra et postopératoire en chirurgie gynécologique par laparoscopie sous anesthésie générale
M. Idrissi, F. Espitalier, M-È Bélanger, V. Brulotte, V. Zaphiratos, C. Loubert, A. Fortier, L-P. Fortier, N. Godin, O. Verdonck, P. Richebé
SFAR, Paris, September 2020 -
Cost-benefit of personalizing intraoperative pain management
Saunders R., Weissbrod R.
ISPOR Virtual Conference, May 2020 -
Performance assessment of the NOL Index during general anesthesia
Shingo Ito, Hiroyuki Seki, Yoshihiko Deguchi, Junko Nakayama, Junko Sannohe, Toshiya Koitabashi
ASA, Orlando, FL, USA, October 2019 -
Quel monitorage de la balance nociception-antinociception peut-on utilizer en OFA (Opioid Free Anesthesia)?
Lewandowski M., Charier D., Meffre S., Zantour D., Toscano R., Bertheaux C., Molliex S.
SFAR, Paris, September 2019 -
Balance nociception-antinociception sous anesthésie générale: quel paramètre d'évaluation?
Meffre S., Charier D., Lewandowski M., Zantour D., Toscano R., Bertheaux C., Molliex S.
SFAR, Paris, September 2019 -
NOL index shows high sensitivity to detect nociception induced by intubation under different remifentanil dosages
Richebé P., McDevitt J., Boselli E., Sbeghen V., Topouzian G.S., Zaphirato V., Fortier L.P., Verdonck O.
CAS, Calgary, June 2019 -
Can NOL index calibration help to individualize remifentanil TCI before skin incision?
Max Bisdorff, Laurent Perrin, Ionut Tabolcea, Edgard Engelman, Luc Barvais
ESA, Vienna, June 2019 -
ED50 and ED95 of remifentanil for tracheal intubation as determined by a monitor of nociception (NOL index)
McDevitt J., Boselli E., Sbeghen V., Topouzian G. S., Verdonck O., Richebé P.
ESA, Vienna, June 2019 -
Anesthesia’s ultimate challenge: monitor intraoperative analgesia
Marta Vidal Seoane, Marta Pérez-De-Lis-Novo, C. Bonome González
ESA, Vienna, June 2019 -
Exploration of the Nociception Level (NOL) Index for Pain Assessment during Endotracheal Suctioning in Mechanically Ventilated Patients in the Intensive Care Unit
Shiva Shahiri, Melissa Richard-Lalonde, Philippe Richebé, Céline Gélinas
CPS, Toronto, Canada, April 2019 -
Nociception Level (NOL)-guided Analgesia: Influence on Opioid Consumption and Hypotensive Events During Propofol/Remifentanil Anesthesia
Albert Dahan. Fleur S. Meijer, Suzanne Broens, Monique van Velzen, Christian Martini.
Awarded as “10 Best of Abstracts: Clinical Science”.
ASA, San Francisco, USA, October 2018 -
Combined Intraoperative Anesthesia & Analgesia Monitoring Impact on Safety & Recovery: CINAAMON Interim Analysis
Etienne Renaud-Roy, Philippe Richebé, Olivier Verdonck, Manon Choinière, Véronique Brulotte, Louis-Philippe Fortier.
ASA, San Francisco, USA, October 2018
CAS Annual Meeting, Montreal, Quebec, Canada, June 2018 -
Impact of Intravenous Phenylephrine Bolus on Intraoperative NOL Index Values
Philippe G.M. Richebe, Véronique Brulotte, Marie-Andree Coulombe, Etienne Renaud-Roy, Omar Elsemin, Manon Choiniere, Pierre Drolet, Louis-Philippe Fortier, Olivier Verdonck.
ASA, San Francisco, USA, October 2018 -
Performance Assessment of the PMD-200 in Subjects Requiring Surgery Under General Anesthesia
Virginia Horne, Borzoo Farhang, Alexander Friend, Max Breidstein.
ASA, San Francisco, USA, October 2018 -
Nol Index Response After Laryngoscopy Performed with Macintosh Blade Versus Glidescope Videolaryngoscope
Virginie Sbeghen, Jason McDevitt, Olivier Verdonck, Valerie Zaphiratos, Veronique Brulotte, Christian Loubert, Pierre A. Drolet, Louis-Philippe Fortier, Marie-Claude Guertin, Philippe Richebé.
ASA, San Francisco, USA, October 2018
2018 CAS Annual Meeting, Montreal, Quebec, Canada, June 2018 -
Douleur Périopératoire et Délirium. Monitorage de La Nociception: Un nouveau paradigme multiparamétrique (NOL)
Dr Pierre-André Stöckle.
NOL technology symposia during SFAR, Paris, France, September 2018 -
Intraoperative nociception monitoring and postoperative recovery after knee arthroplasty
Patricia Lavand’homme, Emmanuel Thienpont.
IASP, Boston, USA, September 2018 -
Detection of Pain under General Anesthesia: Performance Assessment of the PMD-200
Virginia Horne, Alex Friend, Max Breidstein, Borzoo Farhang.
12th Annual New England Anesthesia Residents Conference (NEARC), Boston, Ma, USA, May 2018 -
O noua tehnica non-invaziva pentru monitorizarea durerii si optimizarea analgeziei intraoperatorii: indexul NOL
Serban Bubenek, Ruth Edry.
NOL technology symposia during SRATI congress, Sinaia, Romania, May 2018 -
Nociceptive monitoring during surgery during Mini-symposium: “Monitoring is our future”
Albert Dahan.
Leiden, The Netherlands, March, 2018 -
Missing a Piece? NOL™ (Nociception Level) Technology: Intraoperative Pain Monitoring for Optimizing Analgesia
Ruth Edry, Daniel I. Sessler.
ICISA 2017, Tel Aviv, Israel, Nov. 2017 -
Tailoring analgesia to patients’ needs. The Nociception Level Index (NOL)
Albert Dahan.
3rd Symposium on Anesthesia, Organized by Hospital Da Luz, Lisbon, Portugal, Sept. 2017 -
Comment j’individualise l’analgésie péeriopératoire
Philippe G. Richebe.
SFAR Congress, Paris, France, Sept. 2017 -
Impact of different remifentanil doses on the nociception level index response to intra-operative noxious stimuli
Etienne Renaud-Roy, Pierre-André Stöckle, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
CAS, Niagara Falls, ON, Canada, June 2017 (pages 6-7, abstract no. 274885)
Euroanaesthesia, Geneva, Switzerland, June 2017 (abstract no. 01AP09-6) -
NOL Index performance in patients with beta-blockers
Ruth Edry, Vasile Recea, Yuri Dikust.
Euroanaesthesia, Geneva, Switzerland, May 2017 (abstract no. 08AP05-12) -
Physiologic Indicators for the assessment of acute pain: Recent evidence and new trends
Céline Gélinas.
Canadian Pain Society, May 2017 (p. A36-A37) -
Developing a Monitor Process Perspective
Dr. Ruth Edry – oral presentation at the 2016 Annual Meeting of the Israeli Society of Anesthesiology, December 2016
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Exploring the use of an innovative technology for pain assessment during mediastinal tube removal in cardiac surgery patients in the intensive care unit: The Nociception Level (NOL) Index
Céline Gélinas, Philippe G. Richebé.
ESICM, Milan, Oct. 2016 -
Quantified Analgesic Effect of Intraoperative 50% N2O Inhalation by the NOL and ANI Nociception Indices
Philippe G. Richebe, Elizabeth Decary, Rami Issa, Sarah Maximos, Louis-Philippe Fortier, Olivier Verdonck.
ASA (American Society of Anesthesiologists), Chicago, IL, USA, 2016 -
Nociception Level (NOL) index alteration after standardized nociceptive stimulus decreases with higher doses of remifentanil
Marco Julien, Elizabeth Décary, Rami Issa, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé.
Euronaesthesia – ESA (European Society of Anaesthesiology). London, UK, 2016 -
Ability of the Nociception Level to Detect Noxious Stimuli During Propofol-Remifentanil Anesthesia
Chris Martini, Martijn Boon, Albert Dahan.
ASA (American Society of Anesthesiologists), San Diego, USA, Oct. 2015 -
The Nociception Level (NoL) in Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS) With and Without Thoracic Epidural Analgesia
Laurent Bollag, Srdjan Jelacic, Cynthia Wu, Philippe Richebé.
EFIC Pain Congress, Vienna, Austria, Sept. 2015 -
Validation of a new index for nociception monitoring - NoL™ - during surgery and anesthesia
Ruth Edry, Vasile Recea, Yuri Dikust, Daniel I. Sessler.
Euroanaesthesia – ESA (European Society of Anaesthesiology), Germany, June 2015 (abstract no. 1AP12-6) -
Objective assessment of spinal cord stimulation effectiveness on chronic radicular pain
Nir Ben-Israel, Yariv Amos, Noam Racheli, Mark Kliger, Galit Zuckerman, Roi Treister, Elon Eisenberg.
IASP (International Association for the Study of Pain Annual Meeting), Argentina, Oct. 2014 -
Objective measurement of pain levels in patients with radicular pain treated by spinal cord stimulation
Nir Ben-Israel, Yariv Amos, Mark Kliger, Galit Zuckerman, Erica Suzan, Elon Eisenberg.
AAPM (American Academy of Pain Medicine Annual Meeting), AZ, USA, Mar. 2014 -
Detection of noxious stimuli during general anesthesia using the NOL index for nociception level
Edry Ruth, Kliger Mark, Zuckerman Galit, Racheli Noam, Katz Yeshayahu, Ben-Israel Nir.
Euroanaesthesia – ESA (European Society of Anaesthesiology), Barcelona, Spain, June 2013 -
Non-linear Multi-Parameter Approach for Evaluation of Nociception Level During General Anesthesia
Ben-Israel Nir, Zuckerman Galit, Kliger Mark, Katz Yeshayahu, Edry Ruth.
STA (Society for Technology in Anesthesia), Phoenix, AZ, Jan. 2013
ASA (American Society of Anesthesiologists), Washington DC, Oct. 2012 -
A combination of multiple autonomic parameters, rather than each parameter alone, yields significant differentiation between heat pain intensities
Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg.
EFIC Pain Conference, Germany, 2011 -
Toward automatic pain monitoring: Method for classification of pain level based on statistical processing of multiple non-invasive physiological measures
Roi Treister, Mark Kliger, Galit Zuckerman, Itay Goor Aryeh, Elon Eisenberg.
IPA Conference, Israel, 2010
