Accurate, continuous and noninvasive
Leveraging NOL technology, the PMD-200™ monitoring device quantifies the patient’s physiological response to pain (nociception).
The PMD-200 is designed for the operating room and critical care settings, where patients under general anaesthesia are unable to communicate their pain. The system enables clinicians to assess nociception and objectively titrate analgesics to meet the patient’s specific needs with optimized timing and dosage.
How We Complete the Missing Piece in Anaesthesia
While hypnosis and muscle relaxation can be continuously and specifically monitored during anaesthesia, analgesia has generally been assessed indirectly through changes in heart rate (HR), blood pressure (BP) and other parameters. However, studies have shown that HR and BP are poor surrogates for assessing nociception and adequacy of analgesia.4,5 Therefore, a more reliable and specific nociception monitoring solution is necessary.
NOL technology monitors a constellation of nociception-related physiological responses to reflect a patient’s analgesic needs.
What experts are saying
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1. Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A. (2020). Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial. British Journal of Anaesthesia [In Press]
2. Meijer, F., Martini, C., Broens, S., Boon, M., Niesters, M., Aarts, L., Olofsen, E., van Velzen, M., Dahan, A. (2019). Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial. Anesthesiology, 130(5), 745-755. doi:10.1097/ALN.0000000000002634
3. Saunders R., Weissbrod R. (2020). Cost benefit of personalizing intraoperative pain management. Presented at ISPOR Virtual Conference, May 2020
4. Edry, R., Recea, V., Didust, Y. & Sessler, D. I. (2016). Intraoperative validation of the NOL Index, a non-invasive nociception monitor. Anesthesiology, 125, 193-203.
5. Martini, C. H., Boon, M., Broens, S. J. L., Hekkelman, E. F., Oudhoff, L. A., Buddeke, A. W., Dahan, A. (2015). Ability of the Nociception Level (NOL), a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia. Anesthesiology, 123, 524-534.