Clinical Evidence
NOL monitoring impacting global clinical practice
NOL in Peer-Reviewed Journals
Must Read!
Reduced postoperative pain in patients receiving nociception monitor guided analgesia during elective major abdominal surgery: a randomized, controlled trial
Fuica R, Krocheck C, Weissbrod R, Greenman D, Freundlich A, Gozal Y.
Must Read!
Effect of dexmedetomidine on Nociception Level Index-guided remifentanil antinociception: A randomised controlled trial
Coeckelenbergh, S., Doria, S., Patricio, D., Perrin, L., Engelman, E., Rodriguez, A., Di Marco, L., Van Obbergh, L., Estebe, J., Barvais, L., Kapessidou, P.
Must read!
Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial
Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A.
Must read!
Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial
Fleur Meijer, Chris Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan
Nociception level index-guided antinociception versus routine care during remifentanil-propofol anaesthesia for moderate-to-high risk cardiovascular surgery: A randomized trial
Coeckelenbergh, S., Sessler, D. I., Doria, S., Patricio, D., Jaubert, L., Huybrechts, I., Stefanidis, C., Kapessidou, P., Tuna, T., Engelman, E., Barvais, L., Perrin, L.
Analgesic Efficacy of Erector Spinae Plane Block in Pediatric Abdominal Surgery: Guidance with Conventional Method and NOL: Case Series
Ozdemir, C., Isik, B., Kurtipek, O.
Influence of Intraoperative Nociception during Hip or Knee Arthroplasty with Supplementary Regional Anaesthesia on Postoperative Pain and Opioid Consumption
Neumann C, Gehlen L, Weinhold L, Straßberger-Nerschbach N, Soehle M, Kornilov E, Thudium M.
Generalizability of nociception level as a measure of intraoperative nociceptive stimulation: A retrospective analysis
Ruetzler, K, Montalvo, M, Rotem, OM, Ekrami, E. Rossler, J., Andres, J. Duran, A., Dahan, A. Gozal, Y., Richebe, P., Farhang, B., Turan, A. Sessler, D.I.
Nociception Level Response To Calibrated Stimulations In Children: First Assessment Of The Nociception Level Index In Pediatric Anesthesia
Chemam S, Cailliau E, Bert D, Tavernier B, Constant I, Sabourdin N.
Nociception Control of Bilateral Single-Shot Erector Spinae Plane Block Compared to No Block in Open Heart Surgery—A Post Hoc Analysis of the NESP Randomized Controlled Clinical Trial
Balan C, Tomescu DR, Bubenek-Turconi SI.
Evaluation of the nociception level index in the pediatric population: An observational feasibility study
Klein Tank, C., Himantono, N., van Uitert, A., & Malagon, I.
Nociception Level Index–Guided Intraoperative Analgesia for Improved Postoperative Recovery: A Randomized Trial.
Ruetzler, K, Montalvo, M, Bakal, O, Essber, H, Rössler, J, Mascha, E, Han, Y, Ramachandran, M, Keebler, A, Turan, A, Sessler, D.
Validation of three nociception indices to predict immediate postoperative pain before emergence from general anaesthesia: a prospective double-blind, observational study
Koschmieder K. C., Funcke S., Shadloo M., Pinnschmidt H. O., Greiwe G., Fischer M., & Nitzschke R.
Intraoperative use of the machine learning-derived nociception level monitor results in less pain in the first 90 min after surgery
van der Wal I, Meijer F, Fuica R, Silman Z, Boon M, Martini C, van Velzen M, Dahan A, Niesters M and Gozal Y
Predicting personalised remifentanil effect site concentration for surgical incision using the nociception level index: A prospective calibration and validation study.
Perrin, L., Bisdorff, M., Saxena, S., Tabolcea, I., Huybrechts, I., Van Obbergh, L., Engelman, E., Barvais, L., Coeckelenbergh, S.
The opioid-sparing effect of nociception level (NOL) index monitoring for adult patients undergoing surgery: A systematic review and meta-analysis
Bo Jiao B, Chen M, Wang W, Chen C.