Clinical Evidence
NOL monitoring impacting global clinical practice
NOL in Peer-Reviewed Journals
Must Read!
Reduced postoperative pain in patients receiving nociception monitor guided analgesia during elective major abdominal surgery: a randomized, controlled trial
Fuica R, Krocheck C, Weissbrod R, Greenman D, Freundlich A, Gozal Y.
Must Read!
Effect of dexmedetomidine on Nociception Level Index-guided remifentanil antinociception: A randomised controlled trial
Coeckelenbergh, S., Doria, S., Patricio, D., Perrin, L., Engelman, E., Rodriguez, A., Di Marco, L., Van Obbergh, L., Estebe, J., Barvais, L., Kapessidou, P.
Must read!
Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial
Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A.
Must read!
Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial
Fleur Meijer, Chris Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan
Nociception Level Response To Calibrated Stimulations In Children: First Assessment Of The Nociception Level Index In Pediatric Anesthesia
Chemam S, Cailliau E, Bert D, Tavernier B, Constant I, Sabourdin N.
Nociception Control of Bilateral Single-Shot Erector Spinae Plane Block Compared to No Block in Open Heart Surgery—A Post Hoc Analysis of the NESP Randomized Controlled Clinical Trial
Balan C, Tomescu DR, Bubenek-Turconi SI.
Evaluation of the nociception level index in the pediatric population: An observational feasibility study
Klein Tank, C., Himantono, N., van Uitert, A., & Malagon, I.
Nociception Level Index–Guided Intraoperative Analgesia for Improved Postoperative Recovery: A Randomized Trial.
Ruetzler, K, Montalvo, M, Bakal, O, Essber, H, Rössler, J, Mascha, E, Han, Y, Ramachandran, M, Keebler, A, Turan, A, Sessler, D.
Validation of three nociception indices to predict immediate postoperative pain before emergence from general anaesthesia: a prospective double-blind, observational study
Koschmieder K. C., Funcke S., Shadloo M., Pinnschmidt H. O., Greiwe G., Fischer M., & Nitzschke R.
Intraoperative use of the machine learning-derived nociception level monitor results in less pain in the first 90 min after surgery
van der Wal I, Meijer F, Fuica R, Silman Z, Boon M, Martini C, van Velzen M, Dahan A, Niesters M and Gozal Y
Predicting personalised remifentanil effect site concentration for surgical incision using the nociception level index: A prospective calibration and validation study.
Perrin, L., Bisdorff, M., Saxena, S., Tabolcea, I., Huybrechts, I., Van Obbergh, L., Engelman, E., Barvais, L., Coeckelenbergh, S.
The opioid-sparing effect of nociception level (NOL) index monitoring for adult patients undergoing surgery: A systematic review and meta-analysis
Bo Jiao B, Chen M, Wang W, Chen C.
Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia—A New Era in Patient Safety Standards and Healthcare Management
Rogobete AF, Bedreag OH, Papurica M, Popovici SE, Bratu LM, Rata A, Barsac CR, Maghiar A, Garofil DN, Negrea M, Petcu LB, Toma D, Dumbuleu CM, Rimawi S, Sandesc D.
Nociception Level Index-Directed Erector Spinae Plane Block in Open Heart Surgery: A Randomized Controlled Clinical Trial
Balan C, Tomescu DR, Valeanu L, Morosanu B, Stanculea I, Coman A, Stoian A, Bubenek-Turconi SI.
Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials
Dandan M, Jiahui Ma, Huayong Chen, Dongliang Mu, Hao Kong, Lingzhi Yu
Does NoL monitoring affect opioid consumption during da Vinci prostatectomy?
Niebhagen, F., Golde, C., Koch, T., & Hübler, M