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PMD-200 Launch: New state-of-the-art technology helps clinicians provide personalised pain management

Ramat Gan, Israel, 18 January 2017 — Medasense Biometrics Ltd. announced today that it has received CE mark approval for its novel Pain Monitoring Device, PMD-200This new technology is now available to help physicians objectively assess a patient’s pain in critical care situations, where patients are unable to communicate.  This allows physicians to ensure pain is properly managed.

Using the system will enable physicians, in particular critical care teams, to optimise and personalise pain treatment avoiding over or under use of pain medication that can result in significant complications2,3.  On regaining consciousness after surgery, common complications resulting from opioid administration include nausea, vomiting, respiratory depression, constipation4 and hyperalgesia5. Successful clinical validation studies in world-class European and Canadian hospitals support its use in these settings, with the NOL™ Index demonstrating superior intraoperative pain assessment over currently used methods6,7.

Professor Albert Dahan, MD. PhD. from the Department of Anaesthesiology at Leiden University Medical Center in the Netherlands said, “We have been studying the PMD device for a number of years now, and I believe that the NOL index may allow for more balanced anesthesia, as for the first time we are able to titrate analgesic medication to patients’ needs. In the upcoming weeks the LUMC will be adding PMD200 devices into the operating rooms, in the future I hope to see the NOL index integrated into other monitors as it provides significant decision support information and can potentially positively impact patient outcomes”.

“The European launch of PMD-200 marks a significant milestone for Medasense’s breakthrough pain assessment technology,” said Galit Zuckerman, Medasense’s CEO and founder, “With future products and applications in development, our technology has the potential to dramatically change pain care, pain research and the industry as a whole.”

The company is setting up distribution networks to make the system available in operating rooms and critical care units across Europe.

The company is also conducting research in other forms of pain, for example chronic pain including long-term back pain, with the aim of broadening the situations where the NOL™ Index could help with pain management.


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For the French version of the PR click here

For the Italian version of the PR click here

For the Spanish version of the PR click here

For the Dutch version of the PR click here



  1. Cowen R et al., (2015) Assessing pain objectively: the use of physiological markers. Anaesthesia, 70:828-847
  2. Gan TJ et al., (2014) Incidence, patient satisfaction, and perceptions pf post-surgical pain: Results from a US national survey. Current Medical Research and Opinion. 30:149–60
  3. Pogatzki-Zahn E et al., (2015) A Prospective Multicenter Study to Improve Postoperative Pain: Identification of Potentialities and Problems. Plos One, 10:e0143508
  4. Benyamin R et al., (2008) Opioid Complications and Side Effects. Pain Physician: Opioid Special Issue. 11:S105-S120
  5. Joly V et al., (2005) Remifentanil-induced postoperative hyperalgesia and its prevention with small dose ketamine. Anesthesiology, 103:147-55
  6. Julien M et al., (2016) Nociception Level (NoL) index alteration after standardized nociceptive stimulus decreases with higher doses of remifentanil. Abstract:European Society of Anaesthesiology.
  7. Edry R et al., (2016) Intraoperative validation of the NOL Index, a non-invasive nociception monitor. Anesthesiology, 125:193-203

Video Highlights

The essence of Medasense: Guiding critical care clinicians for optimal pain care

Meeting the challenge of intraoperative pain monitoring

Leading clinicians on the importance of monitoring the patient’s pain response level