Confident Pain Management

Treating Pain is at the
Heart of Medicine

Medasense is the developer of a unique technology that objectively monitors and quantifies the patient’s pain response level using artificial intelligence algorithms and a proprietary noninvasive sensor platform.

NOL technology is used to optimize pain management in critical care settings, where anaesthetized patients are unable to communicate. Recent evidence shows that postoperative pain scores can be reduced by 33% following NOL-guided surgery.1

Interface connectivity is enabled with Philips patient monitors, providing a consolidated view of changes in pain response level alongside vital signs.

The technology is distributed across Europe exclusively by Medtronic, and by leading partners in other regions.

nol technology

Eliminate guesswork and meet clinical challenges in assessing pain and improving analgesia.



Welcome to our online and customized education and training program for clinicians and commercial partners.

Latest News

New study shows that effective opioid-sparing anaesthesia with dexmedetomidine can be guided with NOL pain monitoring technology.


Press release: Monitoring pain response levels during surgery with NOL technology can help reduce postoperative pain as well as healthcare costs.


NOL pain response monitoring has been approved for marketing in Brazil.


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Video Highlights

Medasense - Our Vision: Guiding critical care clinicians for optimal pain care

Meeting the challenge of intraoperative pain monitoring

Leading clinicians on the importance of monitoring the patient’s pain response level

Clinical Collaborations

1. Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A. (2020). Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial. British Journal of Anaesthesia, 125(6), 1070-1078.

2. Meijer, F., Martini, C., Broens, S., Boon, M., Niesters, M., Aarts, L., Olofsen, E., van Velzen, M., Dahan, A. (2019). Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial. Anesthesiology, 130(5), 745-755. doi:10.1097/ALN.0000000000002634

3. Saunders R., Weissbrod R. (2020). Cost benefit of personalizing intraoperative pain management. Presented at ISPOR Virtual Conference, May 2020